The Department of Pediatrics at the University of Texas Medical School at Houston is dedicated to improving the health and welfare of all infants, children, and adolescents.
Dat Q. Tran, M.D.
B.S., in Biochemistry, Tulane University, New Orleans, LA
M.D., Tulane University School of Medicine, New Orleans, LA
Residency, Texas Children’s Hospital, Baylor College of Medicine, Houston, TX
Fellowship, Allergy/Immunology Fellowship, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD
Fellowship, Postdoctoral Clinical Fellow, Laboratory of Immunology, NIAID/NIH, Bethesda, MD
Clinical and Research Interests:
- The study and translational applications of human FOXP3+ regulatory T cells for the understanding and treatment of autoimmunity, immunodysregulation, graft-versus-host disease and cancers.
- The investigation of TGF-beta processing and regulation to develop novel treatments in cancers, inflammation, fibrosis, and autoimmunity.
- Clinical characterization and identification of mechanisms of immune tolerance in patients with IPEX-like syndrome (immunodysregulation, polyendocrinopathy, enteropathy, X-link).
- lkord, E., Alcantar-Orozco, E.M., Dovedi, S.J., Tran, D.Q., Hawkins, R.E. & Gilham, D.E. (2010). T regulatory cells in cancer: recent advances and therapeutic potential. Expert Opinion on Biological Therapy, 10(11), 1573-1586.
- Thornton AM, Korty PE, Tran DQ, Wohlfert EA, Murray PE, Belkaid Y and Shevach EM. Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. Journal of Immunology, 184(7), 3433-3441 (2010).
- Tran DQ, Andersson J, Wang R, Ramsey H, Unutmaz D and Shevach EM. GARP (LRRC32) is essential for the surface expression of latent TGF-b on platelets and activated FOXP3+ regulatory T cells. PNAS, 106(32):13445-50 (2009).
- Tran DQ and Shevach EM. Therapeutic potential of FOXP3+ regulatory T cells and their interactions with dendritic cells. Hum Immunol, 70(5):294-9 (2009).
- Tran DQ, Andersson J and Shevach EM. Selective Expression of Latency Associated Peptide (LAP) and IL-1 Receptors (CD121a/CD121b) on activated human FOXP3+ T regulatory cells allows for their purification in expansion cultures. Blood, 113(21):5125-33 (2009).
- Tran DQ, Glass DD, Uzel G, Darnell DA, Spalding C, Holland SM, and Shevach EM. Analysis of adhesion molecules, target cells and role of interleukin-2 in human FOXP3+ regulatory T cell suppressor function. J Immunol. 2009;182:2929-2938.
- Andersson J, Tran DQ, Pesu M, Davidson TS, Ramsey H, O’Shea J and Shevach EM. CD4+Foxp3+ regulatory T cells confer infectious tolerance in a TGFb-dependent manner. J Exp Med, 205(9):1975-81 (2008).
- Shevach EM, Tran DQ, Davidson TS and Andersson J. The critical contribution of TGF-beta to the induction of Foxp3 expression and regulatory T cell function. Eur J Immunol, 38(4):915-17 (2008).
- Tran DQ, Glass DD and Shevach EM. The suppressive function of human T regulatory cells is contact-mediated and requires interleukin-2. J Allergy and Clinical Immunology, 121(2):S226 (2008).
- Tran DQ, Ramsey R and Shevach EM. Induction of FOXP3 expression in naïve human CD4+FOXP3- T cells by T cell receptor stimulation is TGFb-dependent but does not confer a regulatory phenotype. Blood, 110(8):2983-90 (2007).
- Tran DQ and Shevach EM. TGF-beta stimulated human CD4+CD25-FOXP3- cells express FOXP3, but lack regulatory function. J Allergy and Clinical Immunology, 119(1):S309 (2007).
- Tran DQ. Susceptibility to mycobacterial infections due to interferon-gamma and interleukin-12 pathway defects. Allergy Asthma Proc. 26(5):418-21 (2005)
- Tran DQ, Baliga CS, Hart MC, Clements JD and Pacheco SE. Dose effect of mucosal adjuvant LTR192G on the induction of Th1 and Th2 immunity. J Allergy and Clinical Immunology, 113(2):S290 (2004).
- Tran DQ, Jin L, Chen J, McLachlan JA and Arnold SF. Evaluation of clinical and environmental anti-estrogens with human estrogen receptor expressed in Saccharomyces cerevisiae: A novel role for ABC-cassette transporters in mediating anti-estrogenic activity. Biochem Biophy Res Comm, 235:669-74 (1997).
- Arnold SF, Bergeron JM, Tran DQ, Collins BM, Vonier PM, Crews D, Toscano WA and McLachlan JA. Synergistic responses of steroidal estrogens in vitro (yeast) and in vivo (turtles). Biochem Biophy Res Comm, 235:336-42 (1997)
- Jin L, Tran DQ, Ide CF, McLachlan JA, and Arnold SF. Several synthetic chemicals inhibit progesterone receptor-mediated transactivation in yeast. Biochem Biophy Res Comm, 233:139-46 (1997).
- Tran DQ, Klotz DM, Ladlie BL, Ide CF, McLachlan JA, and Arnold SF. Inhibition of progesterone receptor activity in yeast by synthetic chemicals. Biochem Biophy Res Comm, 229:518-23 (1996).
- Tran DQ, Ide CF, McLachlan JA, and Arnold SF. The anti-estrogenic activity of selected polynuclear aromatic hydrocarbons in yeast expressing human estrogen receptor.Biochem Biophy Res Comm, 229:102-08 (1996).
- Tran DQ, Kow KY, McLachlan JA, and Arnold SF. The inhibition of estrogen receptor-mediated responses by chloro-S-triazine-derived compounds is dependent on estradiol concentration in yeast. Biochem Biophy Res Comm, 227:140-46 (1996).
Location & Contact
6431 Fannin Street
Houston, Texas 77030
- Dat Q. Tran, M.D.
- Department of Pediatrics
Division of Pediatric Research Center & Division of Allergy-Immunology, Rheumatology
- University of Texas-Houston Medical School
6431 Fannin Street, MSB 3.130
Houston, Texas 77030
- phone: (713) 500-5422
fax: (713) 500-5689
Executive Assistant: Patricia McDonald (713) 500-5763