Faculty Biography

Dr. J. Marc Rhoads

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Education:

B.A., Johns Hopkins University, Baltimore, MD

M.D., Johns Hopkins Medical School

Residency, UCLA Hospital and Clinics, Los Angeles, CA

Fellowship, Hospital for Sick Children, Toronto, Ontario, Canada

Clinical and Research Interests:

1. Diarrheal disease, particularly rotavirus diarrhea
2. Infantile colic
3. Irritable bowel syndrome
4. Inflammatory bowel disease

Publications (selected):

• Rhoads JM, Fatheree NY, Norori J, Liu Y, Lucke JF, Tyson JE, and Ferris MJ.  Altered fecal microflora and intestinal inflammation in babies with colic.  J Pediatr., accepted.
• Rhoads JM, Emily Plunkett, Joseph Galanko, Steven Lichtman, Lesli Taylor, Angela Maynor, Timothy Weiner, Katherine Freeman, J Lindhe Guarisco, and GuoYao Wu.  Serum citrulline levels correlate with enteral tolerance and bowel length in infants with short bowel syndrome.   J Pediatr. 2005; 146(4):542-7.
• Becker RM, Wu G, Galanko JA, Chen W, Maynor AR, Bose CL, Rhoads JM.  Reduced serum amino acid concentrations in infants with necrotizing enterocolitis.  J Pediatr.  2000:138:785-793.
• Cutz E, Rhoads JM, Drumm B, Sherman PM, Durie PR, Forstner GG.  Microvillus inclusion disease - An inheritied defect of brush border assembly and differentiation.  New England J Med, 1989;320:646-51.
• Coleman RA, Morris R, van Hove J, Rhoads M, Summar ML.  Cerebral defects and nephrogenic diabetes insipidus with the ARC syndrome:  Additional findings or a new syndrome (ARCC-NDI).  Am J Med Genet. 1997; 72:335-338.
• Worawattanakul M, Rhoads JM, Lichtman SN, Ulshen MH. Abdominal migraine:  Prophylactic treatment and follow-up. J Pediatr Gastroenterology Nutr 1999;28:37-40.
• Rittmeyer C and Rhoads JM.  IgA deficiency causes false negative endomysial antibody results in celiac disease.  J Pediatr Gastroenterology Nutr 1996;23:504-506.

Research Papers:

• Rhoads JM, Liu Y, Niu X, Surendran S, and Wu G.  Arginine stimulates cdx2-transformed intestinal epithelial cell migration via a mechanism requiring both nitric oxide and p70 s6k signaling.  J. Nutr, 138:1652-1657, 2008.
• Benjamin A. Corl, Jack Odle, Xiaomei M. Niu, Adam J. Moeser, Lori A. Gatlin, Oulayvanh T. Phillips, Anthony T. Blikslager, and J. Marc Rhoads.  Arginine Activates Intestinal p70S6k and Protein Synthesis in Piglet Rotavirus Enteritis.  J Nutr.  138:24-29, 2008. 
• Rhoads JM, Corl B, Harrell R, Niu X, Gatlin L, Phillips O, Blikslager A, Moeser A, Wu G, Odle J.  Intestinal ribosomal p70s6k signaling is increased in piglet rotavirus enteritis.  Am J Physiol.  Gastrointest Liver Physiol 2007; Mar;292(3):G913-22.
• J. Marc Rhoads, Xiao Mei Niu, Jack Odle, Jody Gookin, Qiang Fu, and Lee M. Graves.  mTor signaling is required for intestinal cell migration.  Am J Physiol.  Gastrointest Liver Physiol 2006; 291:G510-G517.
• Rhoads JM, Gookin J, Chen W, Wu G, Fu Q, Blikslager AT, Rippe RA, Argenzio RA, Cance WG, Weaver EM, Romer LH.  Arginine stimulates intestinal cell migration through a focal adhesion kinase-dependent mechanism.  Gut, 2004;53: 514-522. 
• JM Rhoads, RA Argenzio, W Chen, LM Graves, LL Licato, AT Blikslager, J Smith, J Gatzy, DA Brenner. Glutamine metabolism stimulates intestinal cell MAPKs by a cAMP-inhibitable, Raf-independent mechanism.  Gastroenterology 2000; 118:90-100.
• Blikslager A, Hunt E, Guerrant R, Rhoads M, Argenzio R.  Glutamine transporter in crypts compensates for loss of villus absorption in bovine cryptosporidiosis.  Am. J. Physiol. 2001; 281(3): G645-G653.
• Rhoads JM, Argenzio RA, Chen W., Gomez GG.  Luminal L-asparagine stimulates piglet intestinal Cl- secre-tion by a mechanism requiring a submucosal glutamate receptor and nitric oxide.  JPET, 1995, 274: 404-412.
• Argenzio RA, Rhoads JM, Armstrong M, and Gomez G.  Glutamine stimulates prostaglandin-sensitive Na+-H+ exchange in experimental porcine cryptosporidiosis.  Gastroenterology 1994;106:1418-1428.
• Argenzio RA and Rhoads JM.  Role of the enteric nervous system in piglet cryptosporidiosis.   J Pharm Exp Ther 1996;279:1109-1115.
• Rhoads JM, Keku EO, Woodard JP, Bangdiwala SI, Lecce JG, and Gatzy JT.  L-glutamine with D-glucose stimulates oxidative metabolism and NaCl absorption in piglet jejunum.  Am J Physiol 1992, 263(Gastrointest Liver Physiol 26):G960-G966.
• Rhoads JM, Keku EO, Quinn J, and Lecce JG.  Glutamine stimulates jejunal sodium and chloride absorption in pig rotavirus enteritis.  Gastroenterology, 1991;100:683-91.

Textbook Chapters:

• Rhoads M and Wu G.  Glutamine, arginine, and leucine signaling in the intestine.   Amino Acids, Springer-Verlag 2008.  Amino Acids (2009) 37:111–122.  DOI 10.1007/s00726-008-0225-4.
• Navarro, F, Gleason W, Rhoads M, and Quiros R.  Short bowel syndrome, Part I (Epidemiology, Pathophysiology, and Adaptation) and Part II (Complications, Treatment, and Remaining Questions).  In AAP NeoReviews.  In press.
• Wu G, Bazer F, Davis T, Kim S, Li P, Rhoads M, Satterfield C, Smith S, Spencer T, and Yin Y.  Arginine metabolism and nutrition in growth, health and disease.  Amino Acids, Springer-Verlag 2008.  Amino Acids (2009) 37:153–168.  DOI 10.1007/s00726-008-0210-y
• Rhoads JM.  Chapter 16:  Short bowel syndrome.  In:  Elsevier Press, Gastroenterology and Nutrition:  Neonatology Questions and Controversies, ed. Josef Neu.  Philadelphia, Saunders Elsevier, 2008:  pp. 292-309.
• Russell WE and Rhoads JM.  Chapter 16:  Humoral regulation of growth.  In Nutrition in Pediatrics, ed. Walker WA, Watkins JB, Duggan C.  Fourth Edition.  277-303.  Fifth edition. 

Location & Contact

6431 Fannin Street
MSB 3.020
Houston, Texas 77030
713-500-5757 (Voice)

Faculty Biography

• Dr. J. Marc Rhoads
  Professor
• Department of Pediatrics
  Division of Gastroenterology & Nutrition
• University of Texas-Houston Medical School
  6431 Fannin Street
  Houston, Texas 77030
• Research & training phone: (713) 500-5663
  fax: (713) 500-5750
  e-mail: j.marc.rhoads@ uth.tmc.edu