Faculty Biography

Hope Northrup, MD

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Education:

B.S.: Biology, College of Charleston, Charleston, South Carolina

M.D.: Medical University of South Carolina, Charleston, South Carolina

Residency: Pediatrics, Southwestern Medical School, Dallas, Texas

Fellowship: Genetics, Institute for Molecular Genetics, Baylor College of Medicine, Houston, Texas

Clinical and Research Interests:

1. Tuberous Sclerosis Complex (TSC)
2. Spina Bifida Cystica
3. Research in my laboratory focuses on two disorders: tuberous sclerosis complex (TSC) and spina bifida cystica. TSC is inherited in an autosomal dominant fashion with two known genes on chromosome 9q34.3 (TSC1) and on chromosome 16p13.3 (TSC2) for the TSC phenotype. Current work underway includes mutational analysis and functional studies of both genes. The spina bifida project is using a candidate gene approach to search for genetic associations.
4. A tutorial in my laboratory will expose the student to common molecular genetic techniques including subcloning, DNA sequencing, Southern blot analysis, single strand conformational polymorphic analysis, cell free transcription-translation, protein-protein interaction techniques, Western blotting and immunoprecipitation.

Publications (selected):

• Platform Presentation: “Further Delineation of Genotype-Phenotype Correlations in Tuberous Sclerosis Complex”. 54th Annual Meeting of the American Society of Human Genetics. Toronto, Canada, October 2004.
• Poster Presentation: “Activation of Phospholipase D in Angiomyolipomas from Tuberous Sclerosis Complex (TSC) Patients”. 54th Annual Meeting of the American Society of Human Genetics. Toronto, Canada, October 2004.
• Presentation: “Testing and Analysis of Folate Metabolism Candidate Genes for Association with Spina Bifida Meningomyelocele”. NTD 2005 and Beyond, Spectrum Neural Tube Defects Conference, Indian Wells, California, September 2005.
• Presentation: “BRCA1 Mutations Show Association with Lesion Location in Spina Bifida Patients”. NTD 2005 and Beyond, Spectrum Neural Tube Defects Conference, Indian Wells, California, September 2005.
• Poster: “Detection of cryptic chromosomal alterations by genome-wide array comparative genomic hybridization (array-CGH) with 21,600 BAC clones”. 55th Annual Meeting of the American Society of Human Genetics. Salt Lake City, Utah, October 2005.
• Poster: “Testing and analysis of folate metabolism candidate genes for association with spina bifida meningomyelocele”. 55th Annual Meeting of the American Society of Human Genetics. Salt Lake City, Utah, October 2005.

 

Location & Contact

6431 Fannin Street
MSB 3.020
Houston, Texas 77030
713-500-5757 (Voice)

Faculty Biography

• Hope Northrup, MD
  Professor
• Department of Pediatrics
  Director, Division of Medical Genetics
• Graduate School of Biomedical Sciences Faculty, University of Texas Health Science Center
• Director, Residency/Fellowship Training Program in Medical Genetics
• Medical Director, Genetic Counseling Training Program
• Director, Medical Genetics Residency Training Program
• Member, Medical and Scientific Staff, Shriners Hospital for Children - Houston Unit
• Co-Director, Training Program in Molecular Genetic Pathology
• University of Texas-Houston Medical School
  6431 Fannin Street, MSB 3.144
  Houston, Texas 77030
• phone: (713) 500.5760
  fax: (713) 500-5689
  e-mail: Hope.Northrup@ uth.tmc.edu
• Administrative Assistant:
  Suzanne Paramore
  (713) 500-5760