Department of Pediatrics
Department of Pediatrics
The Department of Pediatrics

Faculty Biography

The Department of Pediatrics at the University of Texas Medical School at Houston is dedicated to improving the health and welfare of all infants, children, and adolescents.


Dr. Pedro Mancias

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Education:

B.S., Biology, Pan American University, Edinburg, TX

M.D., University of Texas-Houston Medical School

Residency, Pediatrics, UAMS, Little Rock, AR

Residency, Neurology, UT Medical School at Houston

EMG Fellowship, UTHSC, Houston, Texas

Clinical and Research Interests:

  1. Congenital Neuropathies
  2. Congenital Neuromuscular Disorders
  3. Acquired Neuropathies

Publications and Presentations:

  • Glasier CM, Stark JE, Jacobs RF, Mancias P, Leitheiser RE, Seibert RW, Siebert JJ. CT and ultrasound imaging of retropharyngeal abscesses in children. American Journal of Neuroradiology 1992;13:1191-1195.
  • Mancias P, Bohan TP, Butler IJ, Bhattacharjee MB: Treatment-resistant eosinophilic polymyositis in a child. Journal of Child Neurology 1994;9: 446-448.
  • Mancias P, Slopis JM, Yeakley JW, Vriesendorp FJ: Combined brachial plexus injury and root avulsion after complicated delivery [letter]. Muscle & Nerve 1994;17:1237-8.
  • Pagliaro LC, Mancias P: Polymyositis associated with chronic myelogenous leukemia. Annals of Hematology 1994;68:213-4.
  • Mancias P, Kramer L, Butler IJ: Amoxapine overdose in a young man: A transient mitochondrial abnormality? Pharmacotherapy 1995;15: 528-32.
  • Williams J, Grant M, Jackson M, Shema SJ, Sharp G, Griebel M, Lange B, Mancias P, Bates S. Behavioral descriptors that differentiate between seizure and nonseizure events in a pediatric population. Clinical Pediatrics 1996;5:243-9.
  • Pegoraro E, Mancias P, Swerdlow SH, et al: Congenital muscular dystrophy with primary laminin alpha2 (merosin) deficiency presenting as inflammatory myopathy. Annals of Neurology 1996;40:782-91.
  • Pegoraro E, Marks H, Garcia CA, Crawford T, Mancias P, Connolly AM, Fanin M, Martinello F, Trevisan CP, Angelini C, Stella A, Scavina M, Munk RL, Servidei S, Bonnemann CC, Bertorini T, Acsadi G, Thompson CE, Gagnon D, Hoganson G, Carver V, Zimmerman RA, Hoffman EP. Laminin alpha 2 muscular dystrophy: Genotype/phenotype studies of 22 patients. Neurology 1998;51:101-10.
  • Warner LE, Mancias P, Butler IJ, McDonald C, Keppen L, Koob KG, Lupski JR. Mutations in the early growth response 2 (EGR2) gene are associated with hereditary myelinopathies. Nature Genetics 1998;18:382-4.
  • Williams J, Griebel M, Lange B, Dykman R, Bates S, Mancias P, Pihoker C. Does short term AED treatment in children result in cognitive or behavioral changes? Epilepsia 1998;39(10):1064-9.
  • Tseng BS, Cavin ST, Hoffman EP, Iannaccone ST, Mancias P, Booth FW, Butler IJ. Human bHLH transcription factor gene myogenin (MYOG): Genomic sequence and negative mutation analysis in patients with severe congenital myopathies. Genomics 1999;57:419-23.
  • Papanicolaou AC, Panagiotis GS, Brier JI, Wheless JW, Mancias P, Baumgartner JE, Maggio WW, Gormley W, Constantinou JEC, Butler IJ. Brain plasticity for sensory and linguistic functions: A functional imaging study using MEG with children and young adults. J Child Neurol 2001;16:241-52.
  • Boerkoel CF, Takashima H, Garcia CA, Olney RK, Johnson J, Berry K, Russo P, Kennedy S, Teebi AS, Scavina M, Williams LL, Mancias P, Butler IJ, Krajewski K, Shy M, Lupski JR: Charcot-Marie Tooth Disease and related neuropathies: Mutation distribution and genotype-phenotype correlation. Ann Neurol 2002; 51:190-201.
  • Jordanova A, De Jonghe P, Boerkoel CF, Takashima H, De Vriendt E, Ceutrick C, J Martin J, Butler IJ, Mancias P, Papasozomenos S Ch, Terespolski D, Potocki L, Brown CW, Shy M, Rita DA, Tournev I, Kremensky I, Lupski JR, Timmerman V: Mutations in the neurofilament light chain gene (NEFL) cause early onset severe Charcot-Marie-Tooth disease. Brain 2003;126(Pt3):590-7.
  • Boerkoel CF, Takashima H, Nakagawa M, Izumo S, Armstrong D, Butler IJ, Mancias P, Papasozomenos S Ch, Stern LZ, Lupski JR: CMT4A: Identification of a Hispanic Founder mutation. Ann Neurol 2003;53:400-405.
  • Shy ME, Hobson G, Jain M, Boespflug-Tanguy O, Garber J, Sperle K, Li W, Gow A, Rodriguez D, Bertini E, Mancias P, Krajewski K, Lewis R, Kamhoz J. Schwann Cell Expression of PLP1 but Not DM20 is necessary to prevent neuropathy. Ann Neurol 2003;53:354-65.
  • Mancias P, Butler IJ. Trigeminal myokymia in a young girl. Journal of Child Neurology. 2003;18(8):572-574.
  • Inoue K, Khajavi M, Ohyama T, Hirabayashi S, Wilson J, Reggin JD, Mancias P, Butler IJ, Wilkinson MF, Wegner M, Lupski JR. Molecular mechanism for distinct neurological phenotypes conveyed by allelic truncating mutations. Nat Genet. 2004 Apr;36(4):361-9.
  • Heresi GP, Mancias P, Mazur LJ, Butler IJ, Murphy JR, Cleary TG. Poliomyelitis-like syndrome in a child with West Nile virus infection. Pediatr Infect Dis J. 2004 Aug;23(8):788-9.
  • Saifi GM, Szigeti K, Wiszniewski W, Shy ME, Krajewski K, Hausmanowa- Petrusewicz I, Kochanski A, Reeser S, Mancias P, Butler I, Lupski JR. SIMPLE mutations in Charcot-Marie-Tooth disease and the potential role of its protein product in protein degradation. Hum Mutat. 2005 Apr;25(4):372-83.
  • Verhoeven K, Claeys KG, Zuchner S, Schroder JM, Weis J, Ceuterick C, Jordanova A, Nelis E, De Vriendt E, Van Hul M, Seeman P, Mazanec R, Saifi GM, Szigeti K, Mancias P, Butler IJ, Kochanski A, Ryniewicz B, De Bleecker J, Van den Bergh P, Verellen C, Van Coster R, Goemans N, Auer-Grumbach M, Robberecht W, Milic Rasic V, Nevo Y, Tournev I, Guergueltcheva V, Roelens F, Vieregge P, Vinci P, Moreno MT, Christen HJ, Shy ME, Lupski JR, Vance JM, De Jonghe P, Timmerman V. MFN2 mutation distribution and genotype/phenotype correlation in Charcot-Marie-Tooth type 2. Brain. 2006 Aug;129(Pt 8):2093-102.
  • Gruber SA, Mancias P, Swinford RD, Prashner HR, Clifton J, Henry MH. Living-donor nerve transplantation for global obstetric brachial plexus palsy. J Reconstr Microsurg. 2006 May;22(4):245-54.

Presentations

  • Mancias P, Butler IJ. Progressive hemiatrophy and hemineuropathy in a young girl. J Child Neurol 1994.
  • Mancias P, Butler IJ, Paposozomenos S. Natural history of congenital hypomyelinating neuropathy. J Child Neurol.10(2):165, 1995.
  • Mancias P, Mrak R, Hoffman E. Merosin deficiency: Clinical presentation and progression in 3 patients with congenital muscular dystrophy. J Child Neurol.11 (2):154, 1996.
  • Mancias P, Warner LE, Lupski JR, Butler, IJ. Congenital hypomyelinating neuropathy due to a mutation in early growth response transcription factor: EGR2. J Child Neurol. 13:140, 1998.
  • Mancias P, Morrison LA. Guillain Barre syndrome in 2 neonates. J Child Neurol. 15(3): 196, 2000.
  • Shirzadi, S, Mancias P, Butler, IJ. Trigeminal myokymia. J Child Neurol. 15(3): 195, 2000.
  • Shy ME, Garbern J, Mancias P, Lewis RA, Kamholz J. PLP Neuropathies: Proving the Null Hypothesis. Neurology. 54 No. 7 Supplement 3 A70, 2000.
  • Ng, YT, Mancias P, Butler IJ. An unusual cause of congenital club foot. J Child Neurol.16:207, 2001.
  • Acosta Jr F, Mancias P, Butler IJ. Distal asymmetric SMA: A unique entity? Presented at Carrell Krusen Symposium in Dallas, TX February 22, 2002.
  • Mancias P, Heresi G, Butler IJ. Poliomyelitis like illness in a young girl with West Nile virus infection. Presented at Carrel Krusen Symposium in Dallas, TX March 1, 2003.

 

Faculty Biography

Dr. Pedro Mancias
  • Dr. Pedro Mancias
    Associate Professor
  • Departments of Pediatrics and Neurology
    Division of Pediatric Neurology
  • University of Texas-Houston Medical School
    6431 Fannin Street, MSB 7.044
    Houston, Texas 77030
  • phone: (713) 500-7113
    fax: (713) 500-7101
    e-mail: pedro.mancias@ uth.tmc.edu
  • Executive Assistant:
    Nikki Thomason | (713) 500-7113
Click for my PubMed publications