Faculty Biography

Dr. Jacqueline T. Hecht

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Education:

B.S., New York University, Washington Square College, New York, NY

M.S., Human Genetics and Genetic Counseling, University of Colorado Medical Center, Denver, CO

Ph.D., Epidemiology, University of Texas School of Public Health, Houston, TX

Clinical and Research Interests:

1. Identify genes that cause birth defects
   
   
   
   Website: http://ped1.med.uth.tmc.edu/genetics/research
2. Define how mutations in cartilage oligomeric matrix protein (COMP) cause dwarfism:
   
3. Develop therapeutic intervention models
   

Publications and Presentations:

• Hecht, J.T., Hayes, E., Haynes, R., Cole, W.G.: COMP mutations, chondrocyte function and cartilage matrix. Matrix Biol, 23:525-533, 2005.
• Moorthi, R.N., Hashmi, S.S., Langlois, P., Canfield, M., Waller, K., Hecht, J.T.: Idiopathic Talipes Equinovarus (ITEV)(Clubfeet) in Texas. Am J Med Genet, 132A:376-380, 2005.
• Wakui, K., Gregato, G., Ballif, B.C., Glotzbach, C.D., Bailey, K.A., Kuo, P.L., Sue, W.C., Sheffield, L., Irons, M., Gomez, E.G., Hecht, J.T., Potocki, L., Shaffer, L.G.: Construction of a natural panel of 11p11.2 deletions and further delineation of the critical region involved in Potocki-Shaffer syndrome. Eur J Hum Genet, 13:528-540, 2005.
• Hashmi, S.S., Waller, K., Langlois, P., Canfield, M., Hecht, J.T.: Prevalence of Nonsyndromic Oral Clefts in Texas: 1995-1999. Am J Med Genet, 134:368-372, 2005.
• Darilek, S., Wicklund, C., Novy, D., Scott, A., Gambello, M., Johnston, D., Hecht, J.T.: Hereditary Multiple Exostosis and Pain. J Pediatr Orthop, 25:369-376, 2005.
• Saucier, J.B., Johnston, D., Wicklund, C.A., Robbins-Furman, P., Hecht, J.T., Monga, M.: Racial-Ethnic Differences in Genetic Amniocentesis Uptake. J Genet Couns, 14:189-195, 2005.
• Hecht, J.T., Hayes, E., Haynes, R., Cole, W.G., Long, R.J., Farach-Carson, M.C., Carson, D.D.: Differentiation-induced loss of heparan sulfate in human exostosis derived chondrocytes. Differentiation, 73:212-221, 2005.
• Heck, A.L., Bray, M., Scott, A., Blanton, S.H., Hecht, J.T.: Variation in CASP10 gene is associated with Idiopathic Talipes Equinovarus. J Pediatr Orthop, 25:598-602, 2005.
• Chen, F.H., Thomas, A.O., Hecht, J.T., Goldring, M.B., Lawler, J.: Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins. J Biol Chem, 280:32655-61, 2005.
• Blanton, S.H., Cortez, A., Stal, S., Mulliken, J.B., Finnell, R.H., Hecht, J.T.: Variation in IRF6 contributes to nonsyndromic cleft lip and palate. Am J Med Genet, 137:259-62, 2005.
• Posey, K.L., Davies, S., Bales, E., Haynes, R., Sandell, L.J., Hecht, J.T.: In vivo Human Cartilage Oligomeric Matrix Protein (COMP) Promoter Activity. Matrix Biol, 24:539-549, 2005.
• Sage, E.H., Hecht, J.T.: Retention of the Matricellular Protein SPARC in the Endoplasmic Reticulum of Chondrocytes from Patients with Pseudoachondroplasia. J Histochem Cytochem, 54:269-274, 2006.
• Merritt, T.M., Alcorn, J.L., Haynes, R., Hecht, J.T.: Expression of Mutant Cartilage Oligomeric Matrix Protein in Human Chondrocytes Induces the Pseudoachondroplasia Phenotype. J Ortho Res, 24:700-707, 2006.
• Merritt, T.M., Bick, R., Poindexter, B.J., Alcorn, J.L., Hecht, J.T.: Unique matrix structure in the rER cisternae of pseudoachondroplasia chondrocytes. Am J Pathol, 170:293-300, 2007.

 

Location & Contact

6431 Fannin Street
MSB 3.020
Houston, Texas 77030
713-500-5757 (Voice)

Faculty Biography

• Dr. Jacqueline T. Hecht
  Professor (9/1/1997)
• Department of Pediatrics
  Division of Medical Genetics
• University of Texas-Houston Medical School
  6431 Fannin Street, MSB 3.134
  Houston, Texas 77030
• phone: (713) 500-5763
  fax: (713) 500-5689
  e-mail: Jacqueline.T.Hecht@ uth.tmc.edu