Department of Pediatrics
Department of Pediatrics
The Department of Pediatrics

Faculty Biography

The Department of Pediatrics at the University of Texas Medical School at Houston is dedicated to improving the health and welfare of all infants, children, and adolescents.


Ian Butler, MD

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Education:

M.B., B.S. 1964 University of Adelaide, Adelaide, Australia

Resident Medical Officer-Royal Adelaide Hospital, South Australia, 1965.

Resident Medical Officer-Adelaide Children's Hospital, South Australia, 1966.

Medical Registrar-Adelaide Children's Hospital, South Australia, 1967.

Medical Registrar - Royal Children's Hospital, Melbourne, Victoria, Australia, 1968.

Fellow (Neurology) - Department of Pediatrics, University of Melbourne, Royal Children's Hospital, Victoria, Australia, 1969.

Senior House Officer-Department of Neurology/Neurosurgery, The Hospital for Sick Children, Great Ormond Street, London, U.K. 1970.

Registrar in Neurology - Department of Neurology, University Hospital of Wales, Cardiff, U.K. 1971.

Resident in Neurology - Department of Neurology, Johns Hopkins Hospital, Baltimore, Maryland, 1972-73.

Clinical and Research Interests:

  1. Movement disorders of children
  2. Neurometabolic disorders
  3. Neuromuscular disorders
  4. Learning and cognitive disorders of childhood

Publications (selected):

  • Xeroderma Pigmentosum, I.J. Butler, In "The Molecular and Genetic Basis of Neurological Disease." 2nd Ed. Chpt. 54(editors R. N. Rosenberg, S.B. Prusiner, S. DiMauro, R.L. Barchi) Butterworth-Heinemann Publishers MA, Chpt. 54:959-967, 1997.
  • Aromatic L-Amino Acid Decarboxylase Deficiency: Clinical Features, Diagnosis, and Treatment of a Second Family. A. Maller, K. Hyland, S. Milstien, I. Biaggioni, I.J. Butler, J Child Neurol 12:349-354, 1997.
  • Mutations in the Early Growth Response 2(EGR2) Transcription Factor are Associated with Hereditary Myelinopathies. L.E. Warner, P.Mancias, I.J. Butler, C.M. McDonald, L. Keppen, K.G. Koob, J.R. Lupski, Nature Genetics, 18:382-384, 1998.
  • Cerebrospinal Fluid Homovanillic Acid Levels in Rapid-Onset Dystonia - Parkinsonism. A.Brashear, I.J. Butler, K. Hyland, M.R.Farlow, W.B.Dobyns, Annals of Neurol, 43:521-526, 1998.
  • X-Linked Spastic Paraplegia Due to a Mutation (C506T; Ser169Phe) in Exon 4 of the Proteolipid Protein Gene (PLP). M.E. Hodes, A. Hadjisavvas, I.J. Butler, A. Aydanian, S.R. Dlouhy, Am J Med Genet 75:516-517, 1998.
  • Rolandic Type Cerebral Palsy in Children as a Pattern of Hypoxic-Ischemic Injury in the Full Term Neonate. A.I. Maller, L.L. Hankins, J.W. Yeakley, I.J. Butler. J. Child Neurol 13:313-321, 1998.
  • Rapid-Onset Dystonia-Parkinsonism: A Report of Clinical, Biochemical, and Genetic Studies in Two Families. A. Brashear, I.J. Butler, L.J. Ozelius, P.L. Kramer, M.R. Farlow, X.O. Breakefield and W.B. Dobyns, Dystonia 3: Adv Neurol (ed. Fahn, CD Marsden and M DeLong) Lippincott-Raven Publ, Philadelphia, 78:335-339, 1998.
  • Human bHLH Transcription Factor Gene Myogenin(MYOG): Genomic Sequence and Negative Mutation Analysis in Patients with Severe Congenital Myopathies. B. S.Tseng, S.T. Cavin, E.P.Hoffman, S.T. Iannaccone, P. Mancias, F.W. Booth, I.J. Butler. Genomics 57:419-423 1999.
  • Pulmonary Hypoplasia in the Myogenin Null Mouse Embryo. B.S.Tseng, S.T.Cavin, F.W.Booth, E.N.Olson, M.C.Marin, T.J.McDonnell, I.J.Butler. Am.J. Respir Cell & Mol. Biol. 22:304-315, 2000.
  • Recurrent Isolated Ptosis in Presumed Ophthalmoplegic Migraine in Childhood. D.B. Stidham, I.J. Butler, Ophthalmology, 107:1476-1478, 2000.
  • Encephalopathy Associated with Respiratory Syncytial Virus Bronchiolitis . Y-t Ng, C. Cox, J. Atkins, I.J. Butler, J Child Neurol 16:105-108, 2001.
  • Brain Plasticity for Sensory and Linguistic Functions: A Functional Imaging Study Using Magnetoencephalography with Children and Young Adults. A.C. Papanicolaou, P.G. Simos, J.I. Breier, J.W. Wheless, P.Mancias, J.E. Baumgartner, W.W. Maggio, W. Gormley, J.C. Constantinou, I.J. Butler. J Child Neurol 16:241-252, 2001.
  • Neurological and Psychiatric Manifestations in a Family with a Mutation in Exon 2 of the GTP Cyclohydrolase Gene. H. Hahn, M.R. Trant, M.J. Brownstein, R.A. Harper, S. Milstien, I.J. Butler. Arch Neurol 58: 749-755 2001.
  • Sphenoid Sinusitis Masquerading as Migraine Headaches in Children. Y-t Ng, I.J. Butler J Child Neurol 16:882-884, 2001.
  • Education of Medical Students, Pediatricians, and Neurologists in Child Neurology. I.J. Butler. In: Current Management in Child Neurology. 2nd Ed. (Ed: B.L. Maria) B.C. Decker Inc, Hamilton, Canada. Chpt 7 pp 39-49, 2002.
  • Charcot-Marie-Tooth Disease and Related Neuropathies: Mutation Distribution and Genotype –Phenotype Correlation. C.C. Boerkoel H. Takashima, C.A. Garcia, R.K. Olney, J. Johnson, K. Berry, P. Russo, S. Kennedy, A.S. Teebi, M. Scavina, L. L. Williams, P. Mancias, I.J. Butler, K. Krajewski, M. Shy, J.R. Lupski Annals of Neurol 51: 190-201, 2002.
  • Lumbar Spinal Stenosis Causing Congenital Clubfoot. Y-t Ng, P. Mancias, I.J. Butler. J Child Neurol 17: 72-74, 2002.
  • Language Dysfunction in Epileptic Conditions. J.W. Wheless, P.G. Simos, I.J. Butler Diagnosis and Management of Language Disabilities (Guest Ed: Ian J. Butler) Seminars in Pediatric Neurology, (Ed: John B. Bodensteiner) W.B. Saunders, Philadelphia, PA. Vol 9 No 3 p 218-228, 2002.
  • CMT4A: Identification of a Hispanic GDAP1 Founder Mutation C.F. Boerkoel, H. Takashima, M. Nakagawa, S. Izumo, D. Armstrong, I. J. Butler, P. Mancias, S. Ch. Papasozomenos, L. Z. Stern, and J. R. Lupski Annals of Neurol 53: 400-405 2003.
  • Mutations in the Neurofilament Light Chain Gene (NFL) Cause Early Onset Severe Charcot-Marie-Tooth Disease. A. Jordanova, P. DeJonghe, C.F. Boerkoel, H. Takashima, E. DeVriendt, C. Ceuterick, I. J. Butler, P. Mancias, S. Ch. Papasozomenos, D. Terespolski, L. Potocki, C.W. Brown, M. Shy, D. A. Rita, I. Tournev, I. Kremensky, J. R. Lupski, V. Timmerman. Brain 126: 590-597, 2003.
  • Trigeminal Myokymia in a Young Girl. P. Mancias, I.J. Butler. J Child Neurol 18:572-574, 2003.
  • Xeroderma Pigmentosum, Cockayne syndrome and Trichothiodystrophy,. P Mancias, I.J.Butler, In “Neurocutaneous Disorders”, (Ed. E.S. Roach & V.S. Miller) Cambridge University Press, Cambridge, U.K. 29:234-247, 2004
  • Molecular mechanism for distinct neurological phenotypes conveyed by allelic truncating mutations. K. Inoue, M. Khajavi, T. Ohyama, S. Hirabayashi, J. Wilson, J.D. Reggin, P. Mancias, I.J. Butler, M.F. Wilkinson, M. Wegner, and J. R. Lupski. Nature Genetics 36:361-369, 2004.
  • Poliomyelitis-like Syndrome in a Child with West-Nile Virus Infection. G.P. Heresi, L. Mazur, P. Mancias, T.G. Cleary, I.J. Butler The Ped Inf. Dis. J. 23:788-789, 2004.
  • SIMPLE Mutations in Charcot-Marie-Tooth Disease and the Potential Role of Its Protein Product in Protein Degradation. G.M.Saifi, K. Szigeti, W. Wiszniewski, M.E. Shy, K. Krajewski, I. Hausmanowa-Petrusewicz, A. Kochanski, S. Reeser, P. Mancias, I. Butler, and J. Lupski. Human Mutation 25:372-383, 2005.
  • Ischemic Stroke in Children: Heart, Brain, and Mind- A case series of multifactorial ischemic strokes. F.F. Perkins and I.J. Butler. J Child Neurol 20 (7):578-582, 2005.
  • Neuroleptic Malignant Syndrome, Serotonin Syndrome, and Malignant Hyperthermia. Ian Butler, Pedro Mancias. Treatment of Pediatric Neurologic Disorders Edited by Singer/Kossoff/Hartman /Crawford. Taylor & Francis, New York. pp525-530, 2005.
  • Neurologic Complications Associated with Respiratory Syncytial Virus. L.L. Sweetman, Y-t Ng, I.J. Butler, J.B. Bodensteiner. Pediatric Neurol 32(5): 307-310, 2005.
  • MFN2 mutation distribution and genotype/phenotype correlation in Charcot-Marie-Tooth type 2. K. Verhoeven, K.G. Claeys, S. Zuchner, J.M. Schroder, J. Weis, C. Ceuterick, A. Jordanova, E. Nelis, E. De Vriendt, M. Van Hul, P. Seeman, R. Mazanec, S.G. Mustafa, K. Szigeti, P. Mancias, I.J. Butler, A. Kochanski, J. De Bleecker, P. Van den Bergh, C. Verellen, R.V. Coster, V. Rasic, Y. Nevo, F. Roelens, P. Vieregge, P. Vinci, M.T. Moreno, H.J. Christen, M.E. Shy, J.R. Lupski, J.M. Vance, P. De Jonghe, V. Timmerman. Brain 129: 2093-2102, 2006.

BOOKS AND MONOGRAPHS:

  • Diagnosis and Management of Language Disabilities. (Guest Editor: Ian J. Butler) In Seminars in Pediatric Neurology (Editor: John B. Bodensteiner) W.B. Saunders. Philadelphia, PA, Vol. 9 No. 3 (Sept) 2002.

 

Faculty Biography

Ian Butler, MD
  • Ian Butler, MD
    Professor and Division Director
  • Department of Pediatrics and Department of Neurology
  • Director, Division of Pediatric Neurology
  • Staff Neurology Consultant, UT MD Anderson Cancer Center
  • Staff Neurology Consultant, Shriners Hospital for Children, Houston, Texas
  • University of Texas-Houston Medical School
    6431 Fannin Street, MSB 3.020
    Houston, Texas 77030
  • Phone: (713) 500-7113
    Fax: (713) 500-7101
    E-mail: Ian.J.Butler@ uth.tmc.edu
  • Executive Assistant: Nikki Thomason
Click for my PubMed publications