Faculty Biography

Luca Brunelli, MD, PhD

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Education:

M.D., University of Genoa, Genoa, Italy

Ph.D., University of Turin, Turin, Italy

Residency, Pediatrics, University of Genoa, Genoa, Italy

Residency, Anesthesiology, University of Genoa, Genoa, Italy

Residency, Pediatrics, University of Rochester Medical Center, Rochester, New York

Fellowship, Neonatal-Perinatal Medicine, Duke University Medical Center, Durham, North Carolina and Thomas Jefferson University, Philadelphia, Pennsylvania

Clinical and Research Interests:

1. Assisted ventilation of the newborn
2. Transcriptional regulation of 14-3-3 proteins
3. Cardiovascular development

Publications (selected):

• Brunelli L, Hamilton E, Koo H-C, Joseph A, Davis JM, Kazzaz JA, Wolfson MR, Shaffer TH. Perfluorochemical liquids enhance delivery of Superoxide Dismutase to the lungs of juvenile rabbits. Pediatr Res 60:65-70, 2006
• Brunelli L, Yermilov V, Beckman JS. Modulation of catalase peroxidatic and catalatic activity by nitric oxide. Free Rad Biol Med 30:709-714, 2001
• Brunelli L, Crow JP, Beckman JS. The comparative toxicity of nitric oxide and peroxynitrite to Escherichia coli. Arch Biochem Biophys 316:327-334, 1995
• Tao S, Calza G, Lerzo F, Virgone A, Camassa N, Panizzon G, Brunelli L, Moretti R, Grasso P, Ghiggeri GM, Bertolini A. Activation of the intracellular glutathione system by oxidative stress during cardiopulmonary bypass and myocardial perfusion. Perfusion 10:45-50, 1995

Presentations:

• Brunelli L, Cieslik KA, Liou J-Y, Wu KK. PPAR?-dependent 14-3-3? gene expression in human endothelial cells is modulated by the PPAR? ligand 15d-PGJ2 via C/EBP?. E-PAS 59:2890.360, 2006
• Brunelli L, Liou J-Y, Cieslik KA, Tseng H-P, Wu KK. Prostacyclin protects endothelial cell survival via PPAR?-mediated C/EBP? binding to the human 14-3-3? promoter. Circulation 112 (17): II-183, 2005
• Brunelli L, Liou J-Y, Chen H-P, Wu KK. Cloning and characterization of the 14-3-3? promoter: identification of the core region required for PGI2-induced upregulation. PAS 57: 1973, 2005
• Brunelli L, Hamilton E, Koo H-c, Joseph A, Davis JM, Kazzaz JA, Wolfson MR, Shaffer TH. Perfluorochemical liquids (PFC) provide an effective strategy to deliver Superoxide Dismutase to the lungs. Pediatr Res 53:463A, 2003
• Wolfson MR, Brunelli L, Miller T, Koo H-c, Davis, JM, Kazzaz JA, Shaffer TH. Perfluorochemical (PFC) augmented rhSOD delivery attenuates inflammation in acute lung injury. Pediatr Res 53:554A, 2003
• Brunelli L. Nitric oxide and free radicals in neonatal and pediatric intensive care. Symposium of Anesthesia and Intensive Care (SMART), Milan, Italy 1998
• Brunelli L. Oxidants as modulators of cellular activity. 33rd Congress of the International Union of Physiological Sciences (IUPS), St. Petersburg, Russia 1997
• Brunelli L, Koppenol WH, Bertolini A, Beckman JS. Nitric oxide inhibits catalase. Circulation 90 (4, part 2):I-458, 1994
• Brunelli L, Beckman JS. Catalase can scavenge nitric oxide. 9th European Congress of Anesthesiology, Jerusalem, Israel 1994
• Brunelli L, Beckman JS. Nitric oxide requires superoxide to exert bactericidal activity. Free Rad Biol Med 15:499, 1993
• Brunelli L, Calza G, Carrea A, Moretti R, Canepa A, Ghiggeri GM, Perfumo F, Tao S, Bertolini A. Taurine release by the heart during reperfusion in man. Circulation 88 (4, part 2):I-149, 1993
• Dini G, Amici A, Bisio A, Brunelli L, Coleselli P, Corciulo P, et al. for the Italian Cooperative Group. Disseminated neuroblastoma: preliminary results of the AIEOP NB-85 protocol. Bone Marrow Transplant 4 (part 2):58, 1989

 

Location & Contact

6431 Fannin Street
MSB 3.020
Houston, Texas 77030
713-500-5757 (Voice)

Faculty Biography

• Luca Brunelli, MD, PhD
  Assistant Professor
• Department of Pediatrics
  Division of Neonatal-Perinatal Medicine
• University of Texas-Houston Medical School
  6431 Fannin Street, MSB 3.200
  Houston, Texas 77030
• phone office: (713) 500-6422
  phone laboratory: (713) 500-5655
  fax: (713) 500-5794
  e-mail: Luca.Brunelli@ uth.tmc.edu